Job number - ACAD104383
Division/School - Bristol Medical School
Contract type - Fixed Term Contract
Working pattern - Full time
Salary - £38,017-£42,794 per annum
Closing date for applications - 2nd February 2020
Applications are invited for a postdoctoral position to work in the Department of Translational Health Sciences in Bristol Medical School based on Research Floor Level Seven of the Bristol Royal Infirmary.
This is a position for 9 months with Prof Raimondo Ascione.
The project is BHF funded and is assessing the safety and efficacy of consecutive isoprenaline/adenosine (Cons Iso/Ade) to improve myocardial cardioplegic protection in a porcine model of chronic myocardial infarction (MI) with superimposed cardiac surgery.
With support from the BHF, we have shown that the Con-Iso/Ade is strongly cardioprotective in the rat model of MI-induced heart failure and during cardioplegic arrest and that a reduction in oxidative stress and subsequent inhibition of the mitochondrial permeability transition pore opening mediate this protection.
The current project is translating these findings in an advanced porcine model that mimics closely MI and open-heart surgery in humans.
We are testing its safety/efficacy in two interconnected working packages while elucidating mechanistic insights as well as impact on microvascular injury as a final step prior to a first-in-man study.
You will have a PhD (or equivalent) in an appropriate area with essential experience in cardiovascular cellular biology, molecular biology and proficiency with cardiovascular tissue from large animal.
Having Home Office licence, established experience in myocardial oxidative stress, microvascular extra vivo evaluations, gene and protein expression analysis (immunocytochemistry, immunohistochemistry, Western blotting, RT-PCR), large animal work and vascular cell biology would be particularly welcome.
For informal queries please contract Prof Raimondo Ascione - R.Ascione@bristol.ac.uk; 0117 3423286
We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.
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