Panic About Us Site Map Login Register 
European Academic and Research Jobs
Home
 
Job Search
 
Information
 
Login
 
Job Directory | Job Search | Advanced Job Search | Premier Jobs | Institute Profiles | Job Alerts 
Back to the previous page.

+Print
 

Senior Research Associate - Molecular Biology

Organisation's Logo
University of Bristol
 
View all University of Bristol's jobs
Institute Profile
 

Job number - ACAD104383
Division/School - Bristol Medical School
Contract type - Fixed Term Contract
Working pattern - Full time
Salary - 38,017-42,794 per annum
Closing date for applications - 2nd February 2020

Applications are invited for a postdoctoral position to work in the Department of Translational Health Sciences in Bristol Medical School based on Research Floor Level Seven of the Bristol Royal Infirmary.

This is a position for 9 months with Prof Raimondo Ascione.

The project is BHF funded and is assessing the safety and efficacy of consecutive isoprenaline/adenosine (Cons Iso/Ade) to improve myocardial cardioplegic protection in a porcine model of chronic myocardial infarction (MI) with superimposed cardiac surgery.

With support from the BHF, we have shown that the Con-Iso/Ade is strongly cardioprotective in the rat model of MI-induced heart failure and during cardioplegic arrest and that a reduction in oxidative stress and subsequent inhibition of the mitochondrial permeability transition pore opening mediate this protection.

The current project is translating these findings in an advanced porcine model that mimics closely MI and open-heart surgery in humans.

We are testing its safety/efficacy in two interconnected working packages while elucidating mechanistic insights as well as impact on microvascular injury as a final step prior to a first-in-man study.

You will have a PhD (or equivalent) in an appropriate area with essential experience in cardiovascular cellular biology, molecular biology and proficiency with cardiovascular tissue from large animal.

Having Home Office licence, established experience in myocardial oxidative stress, microvascular extra vivo evaluations, gene and protein expression analysis (immunocytochemistry, immunohistochemistry, Western blotting, RT-PCR), large animal work and vascular cell biology would be particularly welcome.

For informal queries please contract Prof Raimondo Ascione - R.Ascione@bristol.ac.uk; 0117 3423286

We welcome applications from all members of our community and are particularly encouraging those from diverse groups, such as members of the LGBT+ and BAME communities, to join us.

Click Here to Apply

Status: Research Scientist
Location: Bristol, UNITED KINGDOM
Advert Published: 13 Jan 2020
Expiry date: 2 Feb 2020
University of Bristol Ref. No.:
ACAD104383
Academic Jobs EU Ref. No.:
Please quote this number if applying for this job offline.
J21532
 

+Send this job to a friend.


+Tell a friend about us.

     Copyright 2018 Academic Jobs EU Ltd. All Rights Reserved  | Privacy Policy