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Postdoc in Radiopharmaceutical Chemistry

Applications are invited from enthusiastic and talented individuals for a postdoc position in radiopharmaceutical chemistry & drug delivery at the Department of Health Technology at the Technical University of Denmark (DTU).

The intended starting date is 1 March 2020 or as soon as possible thereafter.

Project description

As a PhD candidate, you will enter the research program of the Hevesy Laboratory at DTU Health Technology, where you will join our efforts to develop innovative drug delivery systems for treating cancer with radionuclides.

We design, radiolabel and synthesize radioactive drug delivery systems from scratch, using organic and inorganic chemistry, radiochemistry and nanotechnology.

Within this field, your work will focus on developing nanoparticle formulations of the highly potent, radioactive compound [125I]I-UdR, aiming to use these formulations to treat aggressive brain cancer. [125I]I-UdR is used for Auger radiotherapy, since it can insert into the DNA of cancer cells and kill them by emitting a burst of extremely short-ranged electrons. We already know that [125I]I-UdR works extremely well on the cellular level and in rats but in order to use it against brain cancer in humans, we need new nanoparticle based systems that can efficiently distribute and release the compound within the brain.

You will work to develop and prepare these clinically useful nanoparticle formulations, including new chemical methods for loading and releasing [125I]I-UdR. The drug delivery systems will be based on polymeric micelles and liposomes. Further details of the project will be provided at a potential interview.

Drug delivery systems will be developed at the Hevesy Laboratory, DTU Health Tech (RisÝ Campus, Denmark) as well as in the CBIO group, DTU Health Tech (Lyngby Campus, Denmark). Together, we have all the necessary, state-of-the-art equipment for preparing and synthetically modifying radioactive nanoparticles. Biological testing in rats and pigs will be done through our close collaborators at Odense University Hospital (Odense, Denmark), who have long-standing experience with animal testing of [125I]I-UdR. The project will involve significant travelling, including international conference attendance.

You will work as part of a small team dedicated to achieving this goal, including experienced experts in all relevant fields. The project is fully funded by the Independent Research Fund Denmark.

Responsibilities & tasks

The key responsibilities of the successful candidate will include to:

  • Develop and synthesize derivatives of [125I]I-UdR
  • Develop and synthesize polymer-based drug delivery systems
  • Optimize load and release of [125I]I-UdR from drug delivery systems
  • Participate in interpretation of in vivo results
  • Train and supervise at least one PhD student (embedded in the project)
  • Write and publish scientific papers
Further, the successful candidate is expected to communicate with internal and external partners and stakeholders, especially preclinical researchers.

Qualifications

The candidate must have, or be about to obtain, a PhD degree in organic synthesis, radiochemistry, medicinal chemistry, drug delivery or a related field. In addition, the successful candidate must:

  • Have substantial, documented experience with organic synthesis
  • Have experience or interest in drug delivery
  • Have first-authored scientific articles in reputable international journals
  • Have an excellent command of English, both spoken and written
  • Enjoy team-work, networking and frequent communication with colleagues and collaborators
It will also be considered advantageous, but not requirements, that you:

  • Have experience with radiochemistry
  • Have experience with biomedical nanoparticles
  • Have experience with drug delivery to the brain
  • Have experiences with animal models
About the laboratory

The Hevesy Laboratory is the radiochemical and radiopharmaceutical division within DTU Health Tech, with about 25 employees. The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes for use in radioactive pharmaceuticals. The laboratory has chemistry and biology research laboratories and clean rooms, which feature state-of-the-art equipment for working with radioisotopes.

At present, the research group at the Hevesy laboratory consists of an international and dynamic team, focusing on the development of new radioactive pharmaceuticals for diagnostics and therapy. Our research is heavily interdisciplinary and features multiple collaboration partners both locally and internationally. In addition, our in-house GMP team produces radiopharmaceuticals for diagnostics and therapy, which are delivered to local hospitals as well as external collaborators. All professional communication in the research group is done in English.

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The position is full-time, with a fixed term of two years. The employment period starts on March 1st, 2020 or shortly thereafter.

The starting date may be tailored to the right candidate. The primary place of work is The Hevesy Laboratory, DTU Health Tech in Roskilde, Denmark.

Further information

Do not hesitate to contact Senior Scientist Andreas I. Jensen by e-mail or phone for questions and further details, atije@dtu.dk, +45 2012 6187.

Application

Apply online at www.career.dtu.dk.

Please submit your online application no later than 31 January 2020 (local time)

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link Apply online, fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Motivated application letter (max 1 page)
  • Curriculum Vitae
  • PhD degree certificate (if not yet completed, a statement from the main supervisor may suffice)
  • List of publications, including a very brief description of how you contributed.
  • Copy of your academic grade transcripts (masterís and bachelorís degrees), including an official description of how to convert the grades to the European Union (ECTS) or United States (ABC) grading systems
Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies.

Technology for people

DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UNís 17 Sustainable Development Goals. Hans Christian ōrsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.

 

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