King’s School of Cancer and Pharmaceutical Sciences
King’s College London
The salary will be paid at Grade 7 £45,259 to £53,355 per annum, inclusive of £3,223 per annum London Allowance.
This post will be offered on a fixed-term contract for 4 years.
This is a full-time post.
We have recently discovered that in triple negative breast tumours innate lymphoid cell (ILC)3 are recruited by stromal cells to be exploited to ultimately cause the tumour cells to take on a migratory role through a change in the chemokine tumour microenvironment (TME) (Cancer Research DOI:10.1158/0008-5472). We have also identified that within pre-metastatic lymph nodes ILC3 interact with the IL-10 producing transitional B cells. Further, we previously reported on a decrease in NK cells, and increase in Tregulatory (Treg) cells, in the premetastatic lung niche of the same preclinical breast tumour model, which is concomitant with an increase in S100A9 containing extracellular vesicles/exosomes in the interstitium and in close proximity to myeloid derived suppressor cells (MDSC) in the lung tissues (Theranostics 2017;7: 2392-2401).
We are seeking an interactive and self-motivated immunologist (or biologist who has basic immunological skills) to work on imaging the interaction between the innate and adaptive immune components in these premetastatic niches. He/she will image of the relevant cell-cell interactions (and the associated inter-molecular interactions at the interface) in the TME involving basal-like cancer cells, stromal cells and various immune cells e.g. innate lymphoid cells, macrophages, T effector cells and regulatory T/B cells, etc. This postholder will also be involved in the investigations of indirect cell-cell communications via exosomal immune checkpoint molecules such as PD-L1; which is part of a tightly regulated immune surveillance mechanism regulated by the tumor genome-determined balance between exosomal PD-L1 and PD-L1 remaining on tumour cell surface (Cell reports 2018; 24: 630-641). Clinical patient samples will be imaged for validation of the preclinical observation. The post holder would be expected to collaborate with collaborators within the KCL Breast Cancer Now Unit.
The selection process will include a panel interview, an assessment, a presentation.
For an informal discussion to find out more about the role please contact: email@example.com
To apply, please go to: https://bit.ly/2z0zoXo register with the King’s College London application portal and complete your application online.
Closing date: Midnight on 3rd December 2018.