PhD scholarship in radiopharmaceutical chemistry
Applications are invited from enthusiastic and talented individuals for a PhD scholarship in radiopharmaceutical chemistry at the Hevesy Laboratory at DTU Nutech (Risų Campus).
As a PhD candidate, you will enter the research program at the Hevesy Laboratory, and you will work with new innovative drug delivery systems for treating cancer with therapeutic radionuclides. Within this field, you will work on two separate projects: 1) Astatine-211 is an alpha particle emitting radionuclide with great potential in cancer therapy. However, its chemistry and the tendency for astatinated molecules to undergo in vivo degradation and subsequent thyroid accumulation pose show-stopping challenges. Using state-of-art nanoparticle technology in combination with advanced in vivo targeting, you will work to develop clinically useful radiopharmaceuticals based on astatine-211. 2) Auger-therapy is based on radioactive decays where a high amount of very short range electrons are emitted. Therefore, these radionuclides must decay in close proximity to the DNA in order to be effective. If this can be achieved by proper targeting systems, very specific and efficient radiotherapy can be obtained and a new field of internal radiotherapy will open up. The success of Auger therapy thus requires highly advanced delivery strategies, which are currently not available, in combination with specific routes of administration. In this project, you will work on developing Auger-therapy as adjuvant therapy against aggressive brain tumors. Both systems described above will be designed at the molecular level at the Hevesy
Laboratory and initially tested in mouse models, followed by larger animals, and eventually human subjects. The projects will involve a significant amount of travelling, including extended time abroad.
About the department
The Hevesy Laboratory is a radiochemical and radiopharmaceutical division within the Center for Nuclear Technologies (DTU Nutech), with about 25 employees working within this field. The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes, both for PET scans (18F, 64Cu, 89Zr, 52Mn) and internal radiotherapy. These radioisotopes are put to use in radioactive pharmaceuticals. The laboratory has chemistry and biology research laboratories and clean rooms, which feature state of the art equipment for working with radioisotopes.
At present, the research group at the Hevesy laboratory consists of a young and dynamic multidisciplinary team, focusing on the development of new radioactive pharmaceuticals for diagnostics and therapy. This includes the basic chemistry of radiometals and the radiobiology of Auger electron emitting radionuclides. In addition, our in-house GMP team produces radiopharmaceuticals for diagnostics and therapy, which are delivered to local hospitals as well as national and international collaborators.
Candidates must have (or be about to obtain) a master's degree in chemical engineering, chemistry, pharmacy, or similar. The preferred candidate will have a solid foundation in organic synthesis, with knowledge of drug formulation, pharmacology, organometallic chemistry, inorganic chemistry and physiology all being considered advantageous. As a person, you are motivated and ambitious and have a positive mindset. You strive to acquire new skills and knowledge and you are able to work independently if required to. You feel comfortable communicating with other scientists of varying backgrounds and you enjoy engaging in a team effort to achieve excellent results.
Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programs of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.
The assessment of the applicants will be made by Senior Scientist Andreas I. Jensen.
We offer an interesting and challenging job in an international environment focusing on education, research, scientific advice and innovation, which contribute to enhancing the economy and improving social welfare. We strive for academic excellence, collegial respect and freedom tempered by responsibility. The Technical University of Denmark (DTU) is a leading technical university in northern Europe and benchmarks with the best universities in the world.
Salary and appointment terms
The salary and appointment terms are consistent with the current rules for PhD degree students. The period of employment is 3 years. The primary place of work is the Hevesy Laboratory at DTU Nutech , Risų Campus in Roskilde.
You are welcome to contact Senior Scientist Andreas I. Jensen, +45 20126187, firstname.lastname@example.org
The application deadline is the 9th of July 2017.
Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link Apply online, fill in the online application form, and attach all your materials in English in one pdf file. The file must include:
Candidates may apply prior to obtaining their master's degree, but cannot begin before having received it.
- Application Letter
- Curriculum Vitae
- Copy of your academic transcripts
- Excel sheet with translation of grades to the Danish grading system (see guidelines and excel spreadsheet here)
All interested candidates irrespective of age, gender, race, nationality, religion or ethnic background are encouraged to apply.
DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 5,800 advance science and technology to create innovative solutions that meet the demands of society; and our 10,300 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government, and public agencies.